Introduction: Nurses as biggest manpower in health care centers must have evidence-based practices; so, they need to have knowledge about principles of research methodology. According to the scarce attention of nurses to clinical researches, their training and continuing of education is necessary. The aim of this study was to determine the effect of research workshops on nurses’ knowledge.

Methods: This quasi-experimental study was conducted on 90 personnel of Tabriz Medical University in East Azarbaijan province in 2014. Participants were trained in a two-day workshop for 12 hours, using slides and through teamwork. The knowledge of participants was measured before and after the course using a researcher-made questionnaire (the content validity of which was conducted and the reliability of which was approved). Data were analyzed by SPSS version 17 through descriptive statistics and paired t-test.

Results: The difference between mean scores of the pre-test and post-test was statistically significant, and the training course increased the personnel’s knowledge about research methodology. Also, the score of knowledge was significantly correlated with gender and education.

Conclusions: Teaching research methodology in the form of workshop increased the knowledge level of nurses. Due to the importance of evidence-based practices and nurses’ distance from research activities, more attention to continuing education and emphasis on research activities among this population is recommended.